Development and application of the hottest medical

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Development and application of medical plastic packaging film (Part 1)

medical plastic packaging film is widely used, not only for the packaging of tablets, powders, granular drugs, but also for the lining of paste, liquid and drug carton packaging, as well as the packaging of medical devices. The commonly used films include shrink film, winding film, multilayer composite film, etc. In pharmaceutical packaging, the glass bottles and plastic bottles used in the past are gradually replaced by plastic films, especially the plastic flexible packaging of medical liquids, such as infusion bags and plasma bags, is developing more rapidly

according to the survey conducted by American industrial market research company Freedonia grouplnc., the annual average growth rate of global pharmaceutical packaging demand from 1997 to 2007 reached 4.3% (see Table 1). According to the research on the European pharmaceutical packaging market released by the British market intelligence organization, the total annual sales of the European packaging market is $3.246 billion, and the traditional Chinese medicine packaging films and bags account for 28%

the annual output value of China's pharmaceutical packaging industry is about 15billion yuan, with an average annual growth rate of more than 10%. In recent years, the application proportion of plastic products in medical packaging in China is rapidly increasing. Statistics show that the proportion of aluminum and plastic packaging for pharmaceutical tablets in China has increased from 10% in 1990 to 40% at present. Medical plastic film has become a new development hotspot of film. It is estimated that the demand for plastic packaging for pharmaceutical tablets and capsules in China will increase to 4billion in 2005

there are many kinds of medical plastic films, and the widely used ones mainly include PE, PP, pet, pen (polyethylene naphthalate) Pa, PVA, PVC, PVDC, PC and the newly developed cyclic olefin copolymer (COC), among which polyolefin is the largest

diversified development of raw materials

1. Pe

according to the Research Report of mastio on the market situation of PE film, PE medical plastic packaging film is one of the fastest growing varieties of plastic film. It is predicted that the global demand for PE medical plastic film will increase at an average annual rate of 7% in the next few years. The biggest potential growth market of PE medical film is the anti infection medical supplies packaging bag, followed by disposable lining film, small packaging bag and film for medical device packaging. At present, more than 40 companies around the world produce medical PE packaging products. The top five companies are clopay Corp, P1ant, maxxin medical products, Rexam medical packaging and Banta health care, with a market share of about 50%

among PE medical films, LLDPE has the fastest growth in consumption. In 2003, the consumption of LLDPE medical films accounted for 52% of the total consumption of PE medical films in the market, and it is expected to reach 54% in 2006. The main reason for the rapid development of LLDPE medical film is that it can produce films with higher strength than LDPE under the same thickness, so as to produce thin films, save raw materials and reduce costs

in recent years, the annual output of LDPE medical film has exceeded 40000 tons, accounting for 39% of the total consumption in terms of material mechanics, ranking second. The consumption of HDPE and MDPE is small, and the market share is less than 10%

2, pp

the blend of metallocene catalyzed vinyl plastic and PP can improve the embrittlement resistance of PP film after radiation, and can be used in the packaging of medical devices

in recent years, through the modification of PP, it has made great progress in the development of pharmaceutical liquid packaging bags. After screening the raw materials, buxter company believes that if PP is used to make flexible packaging bags for medicinal liquids, it needs to integrate the high melting point of isotactic PP and the elastic block structure of flexible pp. these two materials have excellent softness and flexibility, good low-temperature toughness and a melting point higher than 121oc of the upper and lower ends of the lead screw bearings. At the same time, because their density is about 30% lower than that of PVC, the unit cost is similar to that of PVC. It is reported that the flexible polyolefin fpos of montellcataloy copolymer company and Huntsman company have met the above requirements. At present, rxloy products have been produced in the United States and Asia, and production licenses have been obtained in Europe. However, the crystallinity of fpos is 17%~25% lower than that of PP 99%, and it has a certain viscosity, which is difficult to deal with. Therefore, it is usually necessary to improve its performance through blending. For example, adflexks353 with a density of 0.89g/cm3 must be used as the surface layer to ensure its strength and melting point above 121oc. The surface layer needs to use a special resin with high transparency level to provide the required transparency. In addition, the disadvantage of high haze on PP surface can be overcome through coextrusion process, and the heat sealing performance of PP can be improved through formula design. The result is to delay the healing of bone. With PP resin with density of 0.89g/cm3, the thickness can be reduced and the cost can be reduced

Amoco and Stanford demonstration dual material injection molding system University jointly developed PP elastomer with PVC like properties. MLLDPE developed by Exxon and Dow Chemical Company is also being used in medical liquid flexible packaging bags. They have excellent cleanliness, transparency and mechanical properties, and also have the potential cost advantage of thinning the film thickness. However, mLLDPE has a low melting point and cannot be used to disinfect at 121oc for 20 minutes. Therefore, it is mainly used as a collection bag for human excretion. If it is used as an infusion bag and blood transfusion bag, it needs further modification

in the development process of polyolefin as a substitute material for PVC, because medical products require the use of special polyolefin resin in the processes of disinfection, sterilization, filling, sealing, use and so on, the high cost has become one of the important reasons why polyolefin cannot quickly replace PVC. However, by changing the processing conditions and using new additives, the performance of PP is gradually improving in recent years. In addition, problems related to the assembly line, such as heat sealing and disinfection conditions, can be solved through equipment improvement. Therefore, it is just around the corner that PP film can be used in the fourth generation infusion bags and plasma bags

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